Biostatistics Department

OVATION Project

The OVATION project focuses on improving the interpretation of genetic variants associated with hereditary ovarian and breast cancer. The project integrates large-scale genomic and clinical data from international biobanks and research consortia to build one of the most comprehensive ovarian cancer case-control datasets to date. Using the ccLR framework, OVATION will generate robust statistical evidence to support variant classification and improve risk assessment.
The project EXCELLENCE/0524/0523 is implemented under the programme of social cohesion “THALIA 2021-2027” co-funded by the European Union, through the Research & Innovation Foundation of the Republic of Cyprus.

BcRAVE Project

The BcRAVE project focuses on enhancing statistical methods to identify evidence for variants of uncertain significance (VUS) in breast cancer susceptibility genes that have received limited attention in the past. By improving the understanding of VUS, this research work aims to pave the way for better management of carriers and their families, helping avoid both over-surveillance and under-surveillance. An important aspect of this work involves developing open-source software to make these advancements accessible to the broader research community.
The project OPPTY-MSCA/1223/003 is implemented under the programme of social cohesion “THALIA 2021-2027” co-funded by the European Union, through the Research & Innovation Foundation of the Republic of Cyprus.