Neurogenetics Department

Selected Publications

  • Minaidou A, Nicolaou P, Christodoulou K. Deregulation of LRSAM1 expression impairs the levels of TSG101, UBE2N, VPS28, MDM2 and EGFR. PLoS One. 2019 Feb 6;14(2):e0211814. doi: 10.1371/journal.pone.0211814. eCollection 2019. PMID: 30726272
  • Dardiotis E, Panagiotou E, Siokas V, Aloizou AM, Christodoulou K, Hadjisavvas A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, Kyriakides T. Gene variants of adhesion molecules predispose to Multiple Sclerosis: A case-control Study. Neurol Genet. 2019 Jan 16;5(1):e304. doi: 10.1212/NXG.0000000000000304. eCollection 2019 Feb. PMID: 30697591 
  • Kakouri AC, Christodoulou CC, Zachariou M, Oulas A, Minadakis G, Demetriou CA, Votsi C, Zamba-Papanicolaou E, Christodoulou K, Spyrou GM. Revealing Clusters of Connected Pathways through Multisource Data Integration in Huntington’s disease and Spastic Ataxia. IEEE J Biomed Health Inform. 2019 Jan;23(1):26-37. doi: 10.1109/JBHI.2018.2865569. Epub 2018 Aug 30. PMID: 30176611   
  • Andreou S, Panayiotou E, Michailidou K, Pirpa P, Hadjisavvas A, El Salloukh A, Barnes D, Antoniou A, Christodoulou K, Tanteles G, Kyriakides T. Epidemiology of ATTRV30M neuropathy in Cyprus and the modifier effect of complement C1q on the age of disease onset. Amyloid. 2018 Dec 20:1-7. doi: 10.1080/13506129.2018.1534731. [Epub ahead of print]. PMID: 30572722
  • Malekkou A, Samarani M, Drousiotou A, Votsi C, Sonnino S, Pantzaris M, Chiricozzi E, Zamba-Papanicolaou E, Aureli M, Loberto N, Christodoulou K. Biochemical characterization of the GBA2 c.1780G>C missense mutation in lymphoblastoid cells from patients with spastic ataxia. Int J Mol Sci. 2018 Oct 10;19(10). pii: E3099. doi: 10.3390/ijms19103099. PMID: 30308956
  • Minaidou A, Nicolaou P, Christodoulou K. LRSAM1 depletion affects neuroblastoma SH-SY5Y cell growth and morphology: The LRSAM1 c.2047-1G>A loss-of-function variant fails to rescue the phenotype. Cell J. 2018 Oct;20(3):340-347. doi: 10.22074/cellj.2018.5352. Epub 2018 May 15. PMID: 29845787
  • Konstantopoulos K, Zamba-Papanicolaou E, Christodoulou K. Quantification of dysarthrοphonia in a Cypriot family with autosomal recessive hereditary spastic paraplegia associated with a homozygous SPG11 mutation. Neurol Sci. 2018 May 26. doi: 10.1007/s10072-018-3453-8. [Epub ahead of print]. PMID: 29804168
  • Demetriou CA, Heraclides A, Salafori C, Tanteles GA, Christodoulou K, Christou Y, Zamba-Papanicolaou E. Epidemiology of Huntington disease in Cyprus: a 20 year retrospective study. Clin Genet. 2018 Mar;93(3):656-664. doi: 10.1111/cge.13168. Epub 2018 Feb 8. PMID: 29105741 
  • Dardiotis E, Panagiotou E, Provatas A, Christodoulou K, Hadjisavvas A, Antoniades A, Lourbopoulos A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, Kyriakides T. Gene variants of adhesion molecules act as modifiers of disease severity in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2017 Apr 24;4(4):e350. doi: 10.1212/NXI.0000000000000350. eCollection 2017 Jul. PMID: 28473999
  • Chairta P, Nicolaou P, Christodoulou K. Genomic and Genetic studies of Systemic Sclerosis: a systematic review. Hum Immunol. 2017 Feb;78(2):153-165. doi: 0.1016/j.humimm.2016.10.017. Epub 2016 Oct 29. Review. PMID: 27984087
  • Votsi C, Toufexis C, Michailidou K, Antoniades A, Skordis N, Karaolis M, Pattichis CS, Christodoulou K. Type 2 Diabetes susceptibility in the Greek-Cypriot population: Replication of associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 polymorphisms. Genes (Basel). 2017 Jan 6;8(1). pii: E16. doi: 10.3390/genes8010016. PMID: 28067832
  • Bently DR, Deloukas P, Dunham A, French L, Gregory SG, Humphray SJ, et al. (2001). "The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X". Nature 409:942-943.
  • Bolino A, Muglia M, Conforti FL, LeGuern E, Salih MA, Georgiou DM, Christodoulou K, Hausmanowa-Petrusewicz I, Mandich P, Schenone A, Gambardella A, Bono F, Quattrone A, Devoto M, Monaco AP (2000). "Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2". Nature Genet 25:17-19.
  • Christodoulou K, Zamba E, Tsingis M, Mubaidin A, Horani K, Abu-Sheik S, El-Khateeb M, Kyriacou K, Kyriakides T, Al-Qudah AK, Middleton LT (2000). "Anovel form of distal hereditary motor neuronopathy maps to chromosome 9p21.1-p12". Ann Neurol 48:877-884.
  • Christodoulou K, Tsingis M, Stavrou C, Eleftheriou A, Papapavlou P, Patsalis PC, Ioannou P, Pierides A, Constantinou Deltas C. (1998). "Chromosome 1 localization of a gene for autosomal dominant medullary cystic kidney disease". Hum Mol Genet 7:905-911.
  • Christodoulou K, Tsingis M, Deymeer F, Serdaroglu P, Ozdemir C, Al-Shehap A, Bairactaris C, Mavromatis I, Mylonas I, Evoli A, Kyriallis K, Middleton LT.(1997). "Mapping of the familial infantile myasthenia (congenital myasthenic syndrome type la) gene to chromosome 17p with evidence of genetic homogeneity". Hum Mol Genet. 6:635-40.
  • Christodoulou K, Kyriakides T, Hristova A.H., Georgiou D.M., Kalaydjieva L,Yshpekova B, Ivanova T, Weber JL, Middleton L.T. (1995). "Mapping of a distal form of spinal muscular atrophy with upper limb predominance to chromosome 7p". Hum Mol Genet 4:1629-1632.
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